Long-Term Anesthetic-Dependent Hypoactivity after Repetitive Mild Traumatic Brain Injuries in Adolescent Mice
MouseTBIUnspecifiedC57BL/6MaleAdministered as anaesthesia at the time of each impact
Model: Repetitive mild traumatic brain injury in adolescent mice; single mild TBI versus two or three repetitive injuries each separated by 48 hours, at an injury severity below the threshold for acute neuronal injury
Repetitive mild injuries under Avertin produced transient anxiety and persistent hypoactivity, whereas mice anaesthetised with isoflurane showed no abnormal behaviour even after three injuries and less acute pathology, suggesting isoflurane confers early neuroprotection that can mask long-term defi…
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