Isoflurane-induced Neuroinflammation in Children With Hydrocephalus
Toxicity · Hydrocephalus
Enrolment: 25 · Results not recorded
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Drug · Glycine receptor (alpha-1/beta) positive modulator; GABA-A receptor; anion channel positive allosteric modulator; Potassium channel subfamily K member 10 opener; Potassium channel subfamily K member 18 opener; Potassium channel subfamily K member 3 opener; Potassium channel subfamily K member 9 opener; Potassium channel subfamily K member 2 opener
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Toxicity · Hydrocephalus
Enrolment: 25 · Results not recorded
Delayed Emergence From Anesthesia
Enrolment: 54 · Results not recorded
Anesthesia Recovery Period
Enrolment: 170 · Results not recorded
Valvular Heart Disease · Ischemic Heart Disease
Enrolment: 20 · Results not recorded
Anesthesia
Enrolment: 50 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Controlled cortical impact injury
Deep sedation with isoflurane at minimum alveolar concentration 1.67 or with midazolam increased apoptotic cell counts by 14.8 per cent and 18.0 per cent respectively and worsened neurological outcome, and flumazenil reversed the midazolam effect.
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Model: Repetitive mild traumatic brain injury in adolescent mice; single mild TBI versus two or three repetitive injuries each separated by 48 hours, at an injury severity below the threshold for acute neuronal injury
Repetitive mild injuries under Avertin produced transient anxiety and persistent hypoactivity, whereas mice anaesthetised with isoflurane showed no abnormal behaviour even after three injuries and less acute pathology, suggesting isoflurane confers early neuroprotection that can mask long-term defi…
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Model: Subarachnoid haemorrhage by endovascular perforation of the anterior cerebral artery, with early brain injury
Isoflurane significantly improved neurobehavioural function and brain water content at 24 hours but not at 72 hours. It attenuated cortical neuronal cell death, increased sphingosine kinase 1 and phosphorylated Akt and decreased cleaved caspase-3. These effects were abolished by the sphingosine kin…
Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.