Peripheral Nerve Block Facilitates Acute Inflammatory Responses Induced by Surgical Incision in Mice.
MouseWoundC57BL/6MalePerineural sciatic nerve block0.5% ropivacaineBefore plantar incision
Model: Plantar surgical incision (hind paw) under anaesthesia
The block transiently raised mechanical and thermal thresholds for 2 hours only, with no change from 3 hours onwards, but significantly increased neutrophil infiltration and macrophage clearance of apoptotic cells and up-regulated TNF-alpha, prostaglandin E2, lipoxygenase-15 and haem oxygenase-1 at…
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