Effects of diclofenac sodium on the hippocampus of rats with acute subdural hematoma: histological, stereological, and molecular approach.
RatTBIUnspecifiedSprague DawleyMalen = 24 rats in total, four groupsIntramuscular15 mg/kg dailyFrom the second postoperative hour
Model: Acute subdural haematoma induced by subdural injection of 0.1 ml non-heparinised autologous tail vein blood
Diclofenac sodium given after acute subdural haematoma was associated with a further reduction in hippocampal neuron numbers in CA1, CA2 and CA3 and in total neuron number relative to untreated haematoma, together with necrotic areas, reduced c-FOS positivity, increased PGC-1alpha positivity and hi…
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