THE POTENTIATION OF THE RADIOPROTECTIVE EFFICACY OF TWO MEDICAL COUNTERMEASURES, GAMMA-TOCOTRIENOL AND AMIFOSTINE, BY A COMBINATION PROPHYLACTIC MODALITY.
MouseRadiationCD2F1Malen = n = 16 per survival group; n = 6 per cytokine groupSubcutaneous for both agentsGT3 25 or 50 mg/kg in 0.1 ml; amifostine 30 or 50 mg/kg in…GT3 24 hours before irradiation; amifostine approximately 30 minutes before irr…
Model: Bilateral total body cobalt-60 gamma irradiation, midline dose 9.2 Gy at 0.6 Gy/min
Both agents alone improved 30-day survival relative to vehicle (6%), and every combination group reached 100% survival. With GT3 50 mg/kg, GT3 alone gave 75%, amifostine 50 mg/kg 87.5% and amifostine 30 mg/kg 37.5%; with GT3 25 mg/kg, GT3 alone gave 50%, amifostine 30 mg/kg 44% and amifostine 50 mg…
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