Unfractionated heparin after TBI reduces in vivo cerebrovascular inflammation, brain edema and accelerates cognitive recovery.
MouseTBIControlled cortical impactCD1Malen = 48 animals in total: sham n = 6, injured vehicle n = 14, 75…Subcutaneous75 U/kg or 225 U/kgFirst dose 2 hours after controlled cortical impact
Model: Controlled cortical impact through a 4 mm left parietotemporal craniotomy, 3 mm impactor tip, impact velocity 6 m/s, 1.0 mm cortical deformation
Both heparin doses reduced leukocyte rolling (70.4 to 37.2 and 29.6 cells per 100 micrometres per minute), cerebrovascular albumin leakage (44.3% to 33.3% and 30.1%) and ipsilateral brain water content. Only the 75 U/kg dose improved the Garcia Neurological Test at 24 and 48 hours, while 225 U/kg d…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.