The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice.
MouseEndotoxin/LPSC57BL/6Malen = 35 male C57BL/6 mice in five groups (n = 5 stated in Method…Intraperitoneal1 microgram per gram or 10 micrograms per gram in vivo, in…Pretreatment only; LPS given 24 hours after the third injection
Model: Lipopolysaccharide-induced acute lung injury, intratracheal pharyngeal deposition of 1 microgram per gram LPS (O111:B4) in 50 microlitres saline, assessed at 24 hours
GHK-Cu pretreatment reduced the lung injury score, lavage TNF-alpha and IL-6, myeloperoxidase activity, neutrophil and total cell counts and lavage total protein, and restored lung superoxide dismutase activity and total glutathione, with significance mainly at 10 micrograms per gram. Mechanistical…
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