THERAPY DOSSIER · th-3a488b2cc506

GHK-Cu (glycyl-L-histidyl-L-lysine copper(II) complex)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Endotoxin/LPS
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07437586 ↗Injury indicationPHASE2recruiting

A Phase 2 Study of Topical GHK-Cu (Copper(II)-Peptide Complex) Gel to Accelerate Re-Epithelialization of Standardized Acute Skin Wounds in Healthy Adults

Acute Standardized Cutaneous Wounds

Enrolment: 60 · Results not recorded

NCT05932732 ↗PHASE4completed

A Phase IV Open-label Trial Assessing the Impact on Skin Quality, Hydration, and Barrier of Three Hydrafacial Treatments (ReGen-GF)

Cutis Laxa Facialis · Xeroderma

Enrolment: 27 · Results not recorded

NCT07706361 ↗NAnot yet recruiting

A Two-part Study Investigating the Effect of the X39 Patch on Circulating Blood Levels of GHK and GHK-Cu in a Healthy Adult Population

GHK and GHK-Cu Blood Levels

Enrolment: 100 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27517151 ↗2016Reported benefit

The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice.

MouseEndotoxin/LPSC57BL/6Malen = 35 male C57BL/6 mice in five groups (n = 5 stated in Method…Intraperitoneal1 microgram per gram or 10 micrograms per gram in vivo, in…Pretreatment only; LPS given 24 hours after the third injection

Model: Lipopolysaccharide-induced acute lung injury, intratracheal pharyngeal deposition of 1 microgram per gram LPS (O111:B4) in 50 microlitres saline, assessed at 24 hours

GHK-Cu pretreatment reduced the lung injury score, lavage TNF-alpha and IL-6, myeloperoxidase activity, neutrophil and total cell counts and lavage total protein, and restored lung superoxide dismutase activity and total glutathione, with significance mainly at 10 micrograms per gram. Mechanistical…

Extraction: extract · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.

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