Is the Wnt/beta-catenin pathway involved in the anti-inflammatory activity of glucocorticoids in spinal cord injury?
MouseSpinal cord injuryCompressionMaleMethylprednisolone sodium succinate 6 mg/kg; mometasone fur…Treatment started after induction of spinal cord injury; exact interval not sta…
Model: Surgical spinal cord compression at the T6-T7 level
Both glucocorticoids modulated the Wnt canonical pathway, but mometasone furoate completely restored the downregulated pathway, increased PPAR-gamma more than methylprednisolone and inhibited interleukin 1beta and tumour necrosis factor alpha, indicating greater anti-inflammatory efficacy.
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