Intranasal Steroids (Nasonex) for Nocturnal Enuresis With Obstructive Sleep Apnea
Enuresis · Obstructive Sleep Apnea
Enrolment: 0 · Results not recorded
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Drug · Glucocorticoid receptor agonist (AGONIST); topical/inhaled corticosteroid
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Enuresis · Obstructive Sleep Apnea
Enrolment: 0 · Results not recorded
Chronic Rhinosinusitis Without Nasal Polyps
Enrolment: 288 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Experimental spinal cord injury in mice induced by compression, with a parallel in vitro model of LPS-induced inflammation in J774 macrophage cells
All three glucocorticoids modulated inflammatory, oxidative and apoptotic pathways after compression spinal cord injury, but mometasone furoate was more potent than dexamethasone and methylprednisolone sodium succinate in both the in vitro LPS model and the in vivo injury model, with dexamethasone…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.
Model: Surgical spinal cord compression at the T6-T7 level
Both glucocorticoids modulated the Wnt canonical pathway, but mometasone furoate completely restored the downregulated pathway, increased PPAR-gamma more than methylprednisolone and inhibited interleukin 1beta and tumour necrosis factor alpha, indicating greater anti-inflammatory efficacy.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.