Combined treatment with chondroitinase ABC and treadmill rehabilitation for chronic severe spinal cord injury in adult rats.
RatSpinal cord injuryContusionSprague-DawleyFemaleIntrathecalChondroitinase ABC administered from 6 weeks post-injury; treadmill rehabilitat…
Model: Severe contusive spinal cord injury, chronic phase
Treadmill rehabilitation produced slight recovery between weeks 6 and 9 and chondroitinase ABC stimulated a further phase of recovery between weeks 12 and 14. Chondroitinase ABC-treated rats had greater transverse residual tissue area, more neuronal fibre regeneration caudal to the epicentre and si…
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