THERAPY DOSSIER · th-65049c3ae0c3

Chondroitinase ABC combined with treadmill rehabilitation

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27497528 ↗2016Reported benefit

Combined treatment with chondroitinase ABC and treadmill rehabilitation for chronic severe spinal cord injury in adult rats.

RatSpinal cord injuryContusionSprague-DawleyFemaleIntrathecalChondroitinase ABC administered from 6 weeks post-injury; treadmill rehabilitat…

Model: Severe contusive spinal cord injury, chronic phase

Treadmill rehabilitation produced slight recovery between weeks 6 and 9 and chondroitinase ABC stimulated a further phase of recovery between weeks 12 and 14. Chondroitinase ABC-treated rats had greater transverse residual tissue area, more neuronal fibre regeneration caudal to the epicentre and si…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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