Erythropoietin Restores Long-Term Neurocognitive Function Involving Mechanisms of Neuronal Plasticity in a Model of Hyperoxia-Induced Preterm Brain Injury
RatOtherWistarn = 139 animals total (P7 n=57, P11 n=36, P125 n=44)Intraperitoneal20000 IU/kgAt onset of hyperoxia exposure
Model: Hyperoxia-induced preterm brain injury, 24 h of 80 percent oxygen from postnatal day 6
A single dose at hyperoxia onset improved object recognition and spatial memory from postnatal day 30 to day 90 and reversed downregulation of neuronal plasticity genes, but although acute oligodendrocyte death at P7 was reduced it did not prevent subsequent hypomyelination or long-term white matte…
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