The Effects of Dexamethasone and L-NAME on Acute Lung Injury in Rats with Lung Contusion
RatOtherSprague-Dawleyn = 10 per groupIntraperitonealDexamethasone 15 mg/kg/day; L-NAME 60 mg/kg/day
Model: Blunt lung contusion
Both agents decreased iNOS in contusion groups and dexamethasone increased YKL-40, IL-10 and CC-16, but the combination of high dose steroid with the NOS inhibitor was lethal
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