Alpha2-adrenoreceptor modulated FAK pathway induced by dexmedetomidine attenuates pulmonary microvascular hyper-permeability following kidney injury
MouseIschaemia-reperfusionRenalC57BL/6JMalen = 5-6 per groupIntraperitoneal25 ug/kg15 min before ischaemia or immediately after reperfusion
Model: Bilateral renal pedicle clamping for 45 min followed by 24 h reperfusion, causing acute lung injury
Pre-treatment and post-treatment reduced FITC-albumin leakage by 26 percent and 15 percent respectively, attenuated histological lung injury and increased ZO-1 by 34 percent and VE-cadherin by 26 percent
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