Hyperbaric oxygen preconditioning protects the lung against acute pancreatitis induced injury via attenuating inflammation and oxidative stress in a nitric oxide dependent manner.
RatOtherSprague-DawleyMaleHyperbaric oxygen exposure; L-NAME 40 mg/kg intraperitoneallyPreconditioning: HBO-PC once daily for 3 days, with acute pancreatitis induced…
Model: Acute pancreatitis with associated acute lung injury
HBO-PC reduced blood lipase and amylase, improved lung and pancreatic histology, lowered bronchoalveolar lavage lactate dehydrogenase and protein, suppressed inflammatory factors, reduced malonaldehyde and increased superoxide dismutase activity, and raised lung Nrf2, SOD-1 and HO-1. Pretreatment w…
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