The Effects of Hyperbaric Oxygen Preconditioning On Cardiovascular Protection and Ischaemic Reperfusion Injury
Myocardial Reperfusion Injury · Cytoprotection
Enrolment: 81 · Results not recorded
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2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Myocardial Reperfusion Injury · Cytoprotection
Enrolment: 81 · Results not recorded
Brain Injury · Myocardial Injury
Enrolment: 49 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Simulated high altitude exposure (6000 m for 24 h in hypobaric chamber) inducing acute lung injury
Hyperbaric oxygen preconditioning reduced high altitude-induced lung injury scores and restored AQP1 and AQP5 expression in rat lung.
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Model: Lipopolysaccharide-induced acute lung injury
Hyperbaric oxygen preconditioning lowered lung injury scores, lung water content, hydrogen peroxide and malondialdehyde levels and myeloperoxidase activity, while improving arterial partial pressure of oxygen and superoxide dismutase activity. It inhibited NF-kappa B p65 nuclear translocation and e…
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Model: Acute pancreatitis with associated acute lung injury
HBO-PC reduced blood lipase and amylase, improved lung and pancreatic histology, lowered bronchoalveolar lavage lactate dehydrogenase and protein, suppressed inflammatory factors, reduced malonaldehyde and increased superoxide dismutase activity, and raised lung Nrf2, SOD-1 and HO-1. Pretreatment w…
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Model: Acute spinal cord injury induced by the Allen weight-drop method
Hyperbaric oxygen preconditioning reduced the number of TUNEL-positive apoptotic cells and improved neurological recovery compared with the normal injury and control groups, with statistically significant differences between groups.
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