The effect of pentoxifylline on early and late radiation injury following fractionated irradiation in C3H mice.
MouseRadiationC3HMalen = 104 C3H mice in eight groups of 13, plus 10 unirradiated mi…InjectionProphylactic, continuing after irradiation
Model: Right hind limb irradiation, 4000, 5000, 6000 or 7000 cGy in ten fractions
Pentoxifylline-treated mice had significantly less late injury, most obviously at 5000 and 6000 cGy, with one radiation related death versus seven in saline controls, and 8 per cent (4/51) versus 42 per cent (20/48) with a late score of 3.0 or greater. There was no effect on acute radiation injury…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.