PreImplantation factor (PIF) therapy provides comprehensive protection against radiation induced pathologies.
MouseRadiationC57BL/6; F1 (C57BL/6 x BALB/c)Female and malen = 18 mice per group in the 8 Gy survival study; 14 mice in th…Subcutaneous injection and continuous subcutaneous osmotic pump infusion (0.25 ml/h)0.75 mg/kg or 1.25 mg/kg per injection; 1 mg/kg/day by cont…2 h after lethal irradiation in the primary protocol; 24 h or 48 h after irradi…
Model: Total body irradiation: 8 Gy lethal without bone marrow transplantation, 10 Gy lethal followed by semi-allogeneic or allogeneic bone marrow transplantation, and 6 Gy sub-lethal
PIF given 2 h after 8 Gy lethal irradiation produced 100% survival to day 29 with global haematopoietic recovery at 2 weeks, whereas all PBS control mice died. PIF restored haematopoiesis after 10 Gy with semi-allogeneic bone marrow transplantation, improved long-term engraftment when used to preco…
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