THERAPY DOSSIER · th-3660e556fa23

Synthetic PreImplantation Factor (sPIF)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03593421 ↗PHASE2withdrawn

Phase II Dose Finding Study of Synthetic PreImplantation Factor (sPIF) in Patients With High Panel Reactive Antibodies

Panel Reactive Antibodies

Enrolment: 0 · Results not recorded

NCT03593460 ↗PHASE2withdrawn

Phase II Multiple Dose Finding Study of Synthetic PreImplantation Factor (sPIF) in Patients With Autoimmune Hepatitis

Hepatitis, Autoimmune

Enrolment: 0 · Results not recorded

NCT02239562 ↗PHASE1completed

Phase 1 SAD/MAD Study of Safety, Tolerability and Pharmacokinetics of Synthetic PreImplantation Factor (sPIF) in Autoimmune Hepatitis

Autoimmune Hepatitis

Enrolment: 36 · Results not recorded

NCT00517907 ↗PHASE1unknown

Phase I Trial to Assess Safety of Synthetic Preimplantation Factor (PIF-1) in Steroid-Resistant Acute Graft-Versus-Host Disease After Allogeneic HSCT

Graft Vs Host Disease

Enrolment: 6 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27449294 ↗2016Reported benefit

PreImplantation factor (PIF) therapy provides comprehensive protection against radiation induced pathologies.

MouseRadiationC57BL/6; F1 (C57BL/6 x BALB/c)Female and malen = 18 mice per group in the 8 Gy survival study; 14 mice in th…Subcutaneous injection and continuous subcutaneous osmotic pump infusion (0.25 ml/h)0.75 mg/kg or 1.25 mg/kg per injection; 1 mg/kg/day by cont…2 h after lethal irradiation in the primary protocol; 24 h or 48 h after irradi…

Model: Total body irradiation: 8 Gy lethal without bone marrow transplantation, 10 Gy lethal followed by semi-allogeneic or allogeneic bone marrow transplantation, and 6 Gy sub-lethal

PIF given 2 h after 8 Gy lethal irradiation produced 100% survival to day 29 with global haematopoietic recovery at 2 weeks, whereas all PBS control mice died. PIF restored haematopoiesis after 10 Gy with semi-allogeneic bone marrow transplantation, improved long-term engraftment when used to preco…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

Loading the evidence…