DTI metrics can be used as biomarkers to determine the therapeutic effect of stem cells in acute peripheral nerve injury.
RatCrushPeripheral-nerve crushSprague-DawleyMalen = 44 rats (22 mesenchymal stem cells, 22 phosphate buffered s…Subepineurial microinjection1 week after sciatic nerve crush injury
Model: Sciatic nerve trunk crush injury
Nerves treated with mesenchymal stem cells showed better functional recovery and more pronounced regeneration than phosphate buffered saline controls. Fractional anisotropy and radial diffusivity returned to baseline about one week earlier in treated nerves (p = 0.045 and 0.035), and treated nerves…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.