TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn-induced excessive inflammation via inhibiting activations of P38 and JNK signaling.
RatBurnScaldWistarMalen = 264 Wistar rats in total (first experiment 144 in 6 groups,…Tail vein injection for mesenchymal stem cells and recombinant human TSG-6; intraperitoneal for MAPK inhibitors and balanced salt solutionRecombinant human TSG-6 1 mL of a 50 micrograms/mL solution…Immediately after burn
Model: 50% total body surface area full-thickness scald burn (back 12 s and abdomen 6 s in 94 degrees C water)
Mesenchymal stem cells and recombinant human TSG-6 reduced phosphorylation of P38 and JNK but not ERK, improved burn induced hypothermia and leukopenia, raised IL-10 and lowered TNF-alpha, IL-1beta and IL-6 in serum and organs, and reduced neutrophil and macrophage infiltration in liver, kidney, lu…
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