Protection of Brain Injury by Amniotic Mesenchymal Stromal Cell-Secreted Metabolites.
MouseTBIControlled cortical impactC57Bl/6Intracerebroventricular or intravenous infusion (in vivo); transwell co-culture with cells or conditioned medium (ex vivo)24 hours after injury
Model: Controlled cortical impact traumatic brain injury in mice; oxygen-glucose deprivation in organotypic cortical brain slices
Human amniotic mesenchymal stromal cells given intravenously or intracerebroventricularly produced early and lasting functional and anatomical brain protection. Conditioned medium reproduced the protection ex vivo, and a metabolite-rich subfraction of molecular weight below 700 Da carried the activ…
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