THERAPY DOSSIER · th-2957b0135ae3

Human amniotic mesenchymal stromal cells and their secretome (conditioned medium), including a low molecular weight metabolite-rich fraction

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07723313 ↗EARLY_PHASE1recruiting

Effectiveness of Amniotic Membrane Combined With Secretome as an Adjunct to Carpal Tunnel Release Surgery

Carpal Tunnel Syndrome (CTS)

Enrolment: 30 · Results not recorded

NCT06551649 ↗NArecruiting

Contrasting Chronic Inflammation and Neurodegeneration Using the Human Amniotic Mesenchymal Cell Secretome as an Innovative Therapeutic Strategy

Amyotrophic Lateral Sclerosis · Multiple Sclerosis

Enrolment: 60 · Results not recorded

NCT07721207 ↗NAnot yet recruiting

Ex Vivo Evaluation of the Secretome of Human Amniotic Mesenchymal Stromal Cells in Patients With Chronic Inflammatory Bowel Diseases

Inflammatory Bowel Diseases

Enrolment: 40 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27441900 ↗2016Reported benefit

Protection of Brain Injury by Amniotic Mesenchymal Stromal Cell-Secreted Metabolites.

MouseTBIControlled cortical impactC57Bl/6Intracerebroventricular or intravenous infusion (in vivo); transwell co-culture with cells or conditioned medium (ex vivo)24 hours after injury

Model: Controlled cortical impact traumatic brain injury in mice; oxygen-glucose deprivation in organotypic cortical brain slices

Human amniotic mesenchymal stromal cells given intravenously or intracerebroventricularly produced early and lasting functional and anatomical brain protection. Conditioned medium reproduced the protection ex vivo, and a metabolite-rich subfraction of molecular weight below 700 Da carried the activ…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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