Protective effects of seabuckthorn pulp and seed oils against radiation-induced acute intestinal injury.
MouseRadiationC57BL/6Malen = Mice housed five per cage across radiation and sham groups…Oral administration10 mg/g/day of pulp oil, seed oil or control olive oil; 5 m…Pretreatment for 7 days before irradiation
Model: Single total-body X-ray irradiation of 7.5 Gy at 1.2 Gy/min (RS2000 irradiator) causing acute intestinal injury
Median survival after 7.5 Gy was 4.5 days with control olive oil, 8 days with seed oil and 10 days with pulp oil. Neither oil prevented death but both reduced weight loss, villus damage, apoptotic cell numbers and cleaved caspase 3, and lowered TNF-alpha, IL-1beta, IL-6 and IL-8 mRNA. Both oils pre…
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