THERAPY DOSSIER · th-78b793f5cce2

Seabuckthorn (Hippophae) pulp oil and seed oil; also palmitoleic acid and alpha-linolenic acid

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27422938 ↗2016Reported benefit

Protective effects of seabuckthorn pulp and seed oils against radiation-induced acute intestinal injury.

MouseRadiationC57BL/6Malen = Mice housed five per cage across radiation and sham groups…Oral administration10 mg/g/day of pulp oil, seed oil or control olive oil; 5 m…Pretreatment for 7 days before irradiation

Model: Single total-body X-ray irradiation of 7.5 Gy at 1.2 Gy/min (RS2000 irradiator) causing acute intestinal injury

Median survival after 7.5 Gy was 4.5 days with control olive oil, 8 days with seed oil and 10 days with pulp oil. Neither oil prevented death but both reduced weight loss, villus damage, apoptotic cell numbers and cleaved caspase 3, and lowered TNF-alpha, IL-1beta, IL-6 and IL-8 mRNA. Both oils pre…

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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