Functional and Structural Evaluation of Sildenafil in a Rat Model of Acute Retinal Ischemia/Reperfusion Injury.
RatIschaemia-reperfusionOther / unspecifiedLewisMalen = 38 ratsIntraperitoneal injection0.5 mg/kg and 1 mg/kg once dailyAfter induction of ischaemia-reperfusion injury
Model: Unilateral acute retinal ischaemia-reperfusion injury induced by anterior chamber cannulation
No significant differences in electroretinography, retinal ganglion cell counts or retinal morphometry between sildenafil and saline treated experimental eyes. A non-significant tendency towards less necrosis and slightly lower PDE5, NOS2 and caspase-9 with higher Bcl-2 immunohistochemistry scores…
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