Hydrogen sulphide exacerbates acute pancreatitis by over-activating autophagy via AMPK/mTOR pathway.
RatChemical/toxinWistarMalen = 120 male Wistar rats, 30 per group across four groups (acut…Intraperitoneal injection in vivo; culture medium in vitroIn vivo: sodium hydrosulphide 28 micromol/kg in 1 ml; DL-pr…1 h after induction of acute pancreatitis in vivo; 30 to 60 min before inductio…
Model: Acute pancreatitis induced by retrograde infusion of 3.5% sodium taurocholate (0.15 ml/100 g) into the pancreaticobiliary duct under sodium pentobarbital anaesthesia (40 mg/kg intraperitoneally)
Hydrogen sulphide levels correlated positively with disease severity. Sodium hydrosulphide raised the histological score, HMGB1, pancreatic cytokines, autophagic vacuole accumulation, LC3 conversion, Beclin-1 and trypsinogen activation while lowering p62; DL-propargylglycine did the opposite. Autop…
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