THERAPY DOSSIER · th-fd9ebba88b6b

Sodium hydrosulphide (exogenous hydrogen sulphide donor) and DL-propargylglycine (cystathionine-gamma-lyase inhibitor blocking endogenous hydrogen sulphide synthesis)

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02899364 ↗PHASE2unknown

Groningen Intervention Study for Preservation of Cardiac Function With Sodium Thiosulfate After ST-segment Elevation Myocardial Infarction

Myocardial Infarction · Heart Failure

Enrolment: 380 · Results not recorded

NCT04292184 ↗PHASE1completed

Evaluation of Thiosulfate in End Stage Renal Disease and Kidney Transplantation

End Stage Renal Disease

Enrolment: 18 · Results not recorded

NCT02624479 ↗PHASE1withdrawn

Phase I Pharmacokinetic Pilot Study of Three Different Oral Formulations of Sodium Thiosulfate

Healthy

Enrolment: 0 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 27419805 ↗2016Reported harm

Hydrogen sulphide exacerbates acute pancreatitis by over-activating autophagy via AMPK/mTOR pathway.

RatChemical/toxinWistarMalen = 120 male Wistar rats, 30 per group across four groups (acut…Intraperitoneal injection in vivo; culture medium in vitroIn vivo: sodium hydrosulphide 28 micromol/kg in 1 ml; DL-pr…1 h after induction of acute pancreatitis in vivo; 30 to 60 min before inductio…

Model: Acute pancreatitis induced by retrograde infusion of 3.5% sodium taurocholate (0.15 ml/100 g) into the pancreaticobiliary duct under sodium pentobarbital anaesthesia (40 mg/kg intraperitoneally)

Hydrogen sulphide levels correlated positively with disease severity. Sodium hydrosulphide raised the histological score, HMGB1, pancreatic cytokines, autophagic vacuole accumulation, LC3 conversion, Beclin-1 and trypsinogen activation while lowering p62; DL-propargylglycine did the opposite. Autop…

Extraction: extract · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.

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