The role of Apigenin in testicular damage in experimental ischemia-reperfusion injury in rats.
RatIschaemia-reperfusionOther / unspecifiedWistarMalen = 42 rats in five groupsIntravenous, via the right femoral veinAt the time of detorsion (start of reperfusion)
Model: Testicular torsion-detorsion; left testis rotated 1080 degrees for three hours followed by detorsion and reperfusion
Untreated torsion-detorsion groups showed moderate to severe tubular distortion with grade III to IV lesions, whereas apigenin-treated groups mostly showed grade II to III mild to moderate lesions. TUNEL staining showed a statistically significant reduction in apoptotic cells in apigenin-treated an…
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