Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis
Sepsis · Septic Shock
Enrolment: 20 · Results not recorded
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Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Sepsis · Septic Shock
Enrolment: 20 · Results not recorded
Healthy
Enrolment: 57 · Results not recorded
Healthy
Enrolment: 17 · Results not recorded
Closed Sinus Lift
Enrolment: 22 · Results not recorded
Parkinson Disease
Enrolment: 120 · Results not recorded
3 studies reported at therapy level; 3 evidence entries itemised.
Model: Testicular torsion-detorsion; left testis rotated 1080 degrees for three hours followed by detorsion and reperfusion
Untreated torsion-detorsion groups showed moderate to severe tubular distortion with grade III to IV lesions, whereas apigenin-treated groups mostly showed grade II to III mild to moderate lesions. TUNEL staining showed a statistically significant reduction in apoptotic cells in apigenin-treated an…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Acute pancreatitis induced by bilio-pancreatic duct obstruction close to the duodenum, with secondary acute lung injury
Apigenin reduced most histopathological alterations of lung tissue, lowered myeloperoxidase activity and TNF-alpha at 48 h and IL-6 at 72 h compared with untreated acute pancreatitis controls.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Acetaminophen-induced acute liver injury (350 mg/kg acetaminophen intraperitoneally)
Apigenin pre-treatment lowered serum alanine aminotransferase and aspartate aminotransferase and reduced the severity of liver injury, with significant changes in liver necrosis at 200 mg/kg. Hepatic glutathione reductase activity and reduced glutathione content increased and malondialdehyde decrea…
Extraction: extract · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.