Impact of Superoxide Dismutase-Gliadin on Radiation-induced Fibrosis: An Experimental Study.
MouseRadiationWistar albino (as stated by the authors)Femalen = 36 mice randomly distributed into four groupsOral gavage10,000 units per kg per dayTreatment started 6 months after irradiation
Model: Single 25 Gy irradiation, or sham irradiation, producing radiation-induced skin fibrosis assessed 6 months later
Mean dermal thickness was 0.92 plus or minus 0.23 mm in irradiated placebo-treated mice and 0.71 plus or minus 0.17 mm in irradiated superoxide dismutase-gliadin-treated mice, a statistically significant difference (p equals 0.002), with sham-irradiated values of 0.45 plus or minus 0.09 mm (placebo…
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