Effects of Rosuvastatin and MiR-126 on Myocardial Injury Induced by Acute Myocardial Infarction in Rats: Role of Vascular Endothelial Growth Factor A (VEGF-A).
RatIschaemia-reperfusionCardiacSprague-DawleyMalen = 80 Sprague-Dawley rats in total; control group n=10 and mod…Rosuvastatin by intragastric administration; transfected bone marrow stromal cells injected into the infarct regionAfter induction of acute myocardial infarction
Model: Acute myocardial infarction induced by ligation of the left anterior descending coronary artery
Infarcted rats showed reduced LVEF, fractional shortening and cardiac output with raised ventricular volumes, heart rate and cardiac injury markers, together with down-regulated miR-126 and up-regulated VEGF-A. miR-126 was confirmed to target the VEGF-A 3' UTR by luciferase reporter assay. The auth…
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