Differential effects of glucocorticoid and mineralocorticoid antagonism on anxiety behavior in mild traumatic brain injury.
RatTBIUnspecifiedSprague-DawleyMaleMifepristone 20 mg/kg; spironolactone 50 mg/kg40 min before social defeat stress and mild traumatic brain injury
Model: Acute social defeat stress followed immediately by mild traumatic brain injury
Mifepristone restored open arm time to control levels in defeated rats with mild traumatic brain injury, whereas mineralocorticoid receptor antagonism with spironolactone did not produce the same restoration.
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