THERAPY DOSSIER · th-8577d7474041

Mifepristone (glucocorticoid receptor antagonist) and spironolactone (mineralocorticoid receptor antagonist)

Drug · Glucocorticoid receptor antagonist; Progesterone receptor antagonist (ANTAGONIST)

No trauma translation Suggest a correction

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Glucocorticoid receptor antagonist; Progesterone receptor antagonist (ANTAGONIST)
Target: CHEMBL2034
Injury models: TBI · Burn · Wound
Reported indication: Not recorded
First approval: 2000
Development stage: Not recorded
ChEMBL record: CHEMBL1276308 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Mifepristone; Mifepristona; Mifeprex; Mifegyne; Korlym; RU-486; RU486; RU-38486; NSC-759862
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05341817 ↗PHASE4recruiting

The Use of Letrozole or Mifepristone for Pretreatment of Medical Termination of Pregnancy: a Non-inferiority Trial

Abortion in First Trimester

Enrolment: 144 · Results not recorded

NCT02620904 ↗PHASE4terminated

Mifepristone Induction for Fetal Demise, a Randomized Control Trial

Intrauterine Fetal Demise

Enrolment: 9 · Results not recorded

NCT00936741 ↗PHASE3completed

An Open Label Extension Study of the Efficacy and Safety of CORLUX (Mifepristone) in Endogenous Cushing's Syndrome

Cushing's Syndrome

Enrolment: 30 · Results not recorded

NCT03440866 ↗NAunknown

Comparison of Mifepristone and Misoprostol Concomitantly vs 48-hour Interval for Medical Abortion in Young Pregnancy

Early Pregnancy

Enrolment: 250 · Results not recorded

Preclinical evidence 4

1 studies reported at therapy level; 4 evidence entries itemised.

PMID 27363926 ↗2016Mixed findings

Differential effects of glucocorticoid and mineralocorticoid antagonism on anxiety behavior in mild traumatic brain injury.

RatTBIUnspecifiedSprague-DawleyMaleMifepristone 20 mg/kg; spironolactone 50 mg/kg40 min before social defeat stress and mild traumatic brain injury

Model: Acute social defeat stress followed immediately by mild traumatic brain injury

Mifepristone restored open arm time to control levels in defeated rats with mild traumatic brain injury, whereas mineralocorticoid receptor antagonism with spironolactone did not produce the same restoration.

Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.

PMID 16946078 ↗2007

Burn-induced increase in atrogin-1 and MuRF-1 in skeletal muscle is glucocorticoid independent but downregulated by IGF-I

RatBurn

Extraction: mesh. Machine-extracted fields require source verification.

PMID 7721902 ↗1995

Chronic pathophysiologic elevation of corticosterone after thermal injury or thermal injury and burn wound infection adversely affects body mass, lymphocyte numbers, and outcome

RatBurn

Extraction: mesh. Machine-extracted fields require source verification.

PMID 18708183 ↗2009

Preclinical assessment for selectively disrupting a traumatic memory via postretrieval inhibition of glucocorticoid receptors

RatWound

Extraction: mesh. Machine-extracted fields require source verification.

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