Calendula officinalis ameliorates l-arginine-induced acute necrotizing pancreatitis in rats.
RatChemical/toxinSprague-DawleyMale and femaleOral (p.o.)400 mg/kg
Model: Acute necrotizing pancreatitis induced by two intraperitoneal injections of L-arginine 2 g/kg given 1 hour apart
Extract treatment lowered histopathological scores (score of 2 at day 14) and improved pancreatic nucleic acid content (DNA 21.1 and RNA 5.44 mg/g pancreas), total proteins (0.66 mg/mL pancreas) and pancreatic amylase (1031.3 100 SU/g pancreas). Pancreatic oxidative and nitrosative stress, collagen…
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