Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Chemical/toxin
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 4
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Randomized, Blinded Phase III Trial Comparing Calendula Officinalis Cream With Standard Aqueous Cream 'Essex' for Treatment of Skin Reactions Caused by Postoperative Radiotherapy of Breast Cancer
Postoperative Radiotherapy Breast Cancer
Enrolment: 420 · Results not recorded
Hydration Based on Thoitaine, Aloe Vera and Calendula, in the Prevention of Hand-Foot Syndrome in Patients Using Capecitabine: TACX Care Trial
Hand-foot Syndrome
Enrolment: 54 · Results not recorded
Retrospective Cohort Study Comparing a Novel Silicone Gel Wound Dressing vs Standard of Care in the Treatment of Radiation Dermatitis (Calendula comparator arm)
Radiation Dermatitis
Enrolment: 344 · Results not recorded
A Randomized Intra-Patient Controlled Study of StrataXRT vs Current Practice to Prevent and Treat Radiation Dermatitis (Calendula ointment arm)
Breast Carcinoma · Head and Neck Carcinoma · Radiation-Induced Dermatitis
Enrolment: 0 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatChemical/toxinSprague-DawleyMale and femaleOral (p.o.)400 mg/kg
Model: Acute necrotizing pancreatitis induced by two intraperitoneal injections of L-arginine 2 g/kg given 1 hour apart
Extract treatment lowered histopathological scores (score of 2 at day 14) and improved pancreatic nucleic acid content (DNA 21.1 and RNA 5.44 mg/g pancreas), total proteins (0.66 mg/mL pancreas) and pancreatic amylase (1031.3 100 SU/g pancreas). Pancreatic oxidative and nitrosative stress, collagen…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.