Lactoferrin during lactation reduces lipopolysaccharide-induced brain injury.
RatEndotoxin/LPSMaternal dietary supplementation during lactationSupplemented in maternal food throughout lactation, with lipopolysaccharide inj…
Model: Lipopolysaccharide injected into the subcortical white matter of rat pups at postnatal day 3, modelling preterm inflammatory brain injury
Lactoferrin reduced lipopolysaccharide-induced ventriculomegaly, brain tissue loss and microstructural change including myelination deficit, and limited alteration of the 1H-MRS neurochemical profile through an antioxidant action, with less microglial activation. There was no effect on lipopolysacc…
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