Tumor necrosis factor-α antagonist suppresses local inflammatory reaction and facilitates olfactory nerve recovery following injury.
MouseOtherOlfactory marker protein transgenic mice (OMP-tau-lacZ)Male and femaleIntraperitoneal injectionImmediately after olfactory nerve transection
Model: Olfactory nerve transection (NTx)
TNF-alpha expression rose in the olfactory bulb within hours of nerve transection. Etanercept-treated mice had significantly smaller areas of injury-associated tissue, fewer astrocytes and macrophages or microglia, and more regenerating nerve fibres, with improved olfactory function on both avoidan…
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