Trial title not recorded
Arthritis, Rheumatoid
Enrolment: 42 · Results not recorded
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Biologic · TNF-alpha inhibitor (INHIBITOR)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Arthritis, Rheumatoid
Enrolment: 42 · Results not recorded
Type 1 Diabetes Mellitus
Enrolment: 48 · Results not recorded
Rheumatoid Arthritis · Psoriatic Arthritis
Enrolment: 60 · Results not recorded
SAPHO Syndrome
Enrolment: 60 · Results not recorded
Gulf War Illness · Persian Gulf Syndrome · Occupational Diseases
Enrolment: 20 · Results not recorded
Inclusion Body Myositis
Enrolment: 20 · Results not recorded
Pediatric Psoriasis
Enrolment: 0 · Results not recorded
9 studies reported at therapy level; 11 evidence entries itemised.
Model: Thoracic spinal cord injury
Etanercept reduced neuronal and oligodendroglial apoptosis, limited tissue damage, promoted myelination and improved hindlimb locomotion after spinal cord injury.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Unilateral optic nerve crush with jeweller's forceps for 10 seconds approximately 1 mm behind the optic disc, and sonication-induced traumatic optic neuropathy (ultrasound shockwave)
Etanercept increased retinal ganglion cell survival relative to vehicle in both models (crush 49 +/- 2 per cent versus 25 +/- 1 per cent of the uninjured fellow eye; sonication 97 +/- 2 per cent versus 77 +/- 2 per cent; both p less than 0.01) and raised pattern electroretinogram a-wave amplitudes…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: Non-penetrating experimental head injury
Dexamethasone differed significantly from saline only for oedema and inflammation, with no difference for neuronal damage, astrocytic damage or glial apoptosis. Etanercept differed significantly from both saline and dexamethasone across all variables, indicating anti-oedematous, anti-inflammatory a…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Olfactory nerve transection (NTx)
TNF-alpha expression rose in the olfactory bulb within hours of nerve transection. Etanercept-treated mice had significantly smaller areas of injury-associated tissue, fewer astrocytes and macrophages or microglia, and more regenerating nerve fibres, with improved olfactory function on both avoidan…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Lipopolysaccharide-induced acute lung and liver injury on a background of 6 weeks of chronic ethanol exposure (Lieber-DeCarli diet)
Chronic ethanol pre-exposure enhanced both liver and lung injury caused by lipopolysaccharide. Systemic TNF-alpha depletion with etanercept blunted the injury and the increase in MIP-2 and KC in the lung caused by the combination of ethanol and LPS.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Postischaemic acute kidney injury (renal ischaemia-reperfusion), with long-term follow-up to 5 weeks; bacterial CpG DNA injection used as an additional TLR9 challenge in wild-type mice
Wild-type kidneys regenerated completely within 5 weeks of acute kidney injury, whereas IRAK-M deficient kidneys progressively lost up to two-thirds of their original mass through tubule loss, with interstitial M1 macrophage accumulation and increased proinflammatory cytokine and chemokine expressi…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Lateral fluid percussion injury through a 4.8 mm craniotomy 3.0 mm right of the central suture
Etanercept was detectable in contused brain tissue and reduced neurological and motor deficits, contusion area and brain TNF-alpha while increasing BrdU and doublecortin double-positive cells.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Murine kidney ischaemia-reperfusion injury causing ischaemic acute kidney injury with remote lung injury
Disruption of TNF-alpha signalling with etanercept implicated circulating TNF-alpha as a key mediator of pulmonary apoptosis and lung microvascular barrier dysfunction during ischaemic acute kidney injury, while inhibition of NF-kappaB produced a proapoptotic phenotype and barrier leak independent…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Spinal cord contusion injury
Early etanercept suppressed TNF-alpha and apoptosis of transplanted neural stem cells, and combination therapy improved locomotor recovery, ventral horn neuron survival, cavity size, neurofilament-positive fibres and axon myelination.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
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Extraction: mesh. Machine-extracted fields require source verification.