Sanguinate's effect on pial arterioles in healthy rats and cerebral oxygen tension after controlled cortical impact.
RatTBIControlled cortical impactSprague-DawleyMaleIntravenousStudy 1: four serial infusions at 8 mL/kg/h, cumulative 16…Study 2: 15 min after controlled cortical impact. Study 1: healthy rats, no inj…
Model: Controlled cortical impact traumatic brain injury (Study 2); healthy anaesthetised rats with cranial window (Study 1)
Sanguinate did not change pial arteriolar diameter in healthy rats relative to Hextend or saline, and did not acutely raise brain tissue oxygen pressure after traumatic brain injury (PbtO2 fell from 36.5 +/- 3.9 to 19.8 +/- 3.0 mmHg at 15 min in both groups and did not recover). Mean arterial press…
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