SANGUINATE to reduce delayed graft function after brain-death donor kidney transplant
Delayed Function of Renal Transplant
Enrolment: 60 · Results not recorded
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Biologic · ChEMBL NOT QUERIED: PEGylated bovine carboxyhaemoglobin, a formulated protein oxygen carrier with no discrete ChEMBL entity; resolved=false by entity class. 8 EXACT SANGUINATE trials recorded plus NCT04677777 PP-007, the same Prolong Pharmaceuticals PEG-carboxyhaemoglobin under its later designation. NCT01925001 MP4CO (Sangart) EXCLUDED: a different PEGylated haemoglobin product. No SANGUINATE trial is trauma-specific; indications are sickle cell disease, anaemia, SAH, stroke and delayed graft function.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Delayed Function of Renal Transplant
Enrolment: 60 · Results not recorded
Anemia, Sickle Cell
Enrolment: 34 · Results not recorded
Cerebral Ischemia
Enrolment: 12 · Results not recorded
Leg Ulcer
Enrolment: 10 · Results not recorded
Delayed Function of Renal Transplant
Enrolment: 0 · Results not recorded
Acute Anemia
Enrolment: 103 · Results not recorded
Sickle Cell Disease
Enrolment: 24 · Results not recorded
Drug Safety
Enrolment: 2 · Results not recorded
Acute Ischemic Stroke
Enrolment: 24 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Controlled cortical impact traumatic brain injury (Study 2); healthy anaesthetised rats with cranial window (Study 1)
Sanguinate did not change pial arteriolar diameter in healthy rats relative to Hextend or saline, and did not acutely raise brain tissue oxygen pressure after traumatic brain injury (PbtO2 fell from 36.5 +/- 3.9 to 19.8 +/- 3.0 mmHg at 15 min in both groups and did not recover). Mean arterial press…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.