Hypoxia-induced pulmonary arterial hypertension augments lung injury and airway reactivity caused by ozone exposure.
MouseChemical/toxinC57BL/6Malen = n=4-8 per treatment group for right ventricular pressure me…Intraperitoneal20 mg/kgFirst dose before ozone exposure, second dose after ozone exposure
Model: Acute ozone-induced lung injury (4 h, 1 ppm ozone or filtered air) superimposed on 3 weeks of continuous hypoxia (10.0% O2) induced pulmonary arterial hypertension, versus normoxia (20.9% O2)
Hypoxia raised right ventricular pressure and produced right ventricular hypertrophy. Ozone alone caused airway inflammation in normoxic mice, while combined hypoxia and ozone markedly increased lung weight, lung water, bronchoalveolar lavage cellularity and methacholine-induced airway resistance.…
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