Rapamycin suppresses microglial activation and reduces the development of neuropathic pain after spinal cord injury.

Rapamycin suppresses microglial activation and reduces the development of neuropathic pain after spinal cord injury.

Model: Thoracic spinal cord contusion injury

Rapamycin inhibited mTOR signalling in the injured cord and significantly improved locomotor function and reduced mechanical and thermal hypersensitivity. Iba-1 stained microglia and p38 MAPK activity in the lumbar spinal cord were significantly decreased, indicating attenuated development of neuro…

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