Olfactory Ensheathing Cell Transplantation after a Complete Spinal Cord Transection Mediates Neuroprotective and Immunomodulatory Mechanisms to Facilitate Regeneration.
RatSpinal cord injuryComplete transectionSprague-Dawley (including transgenic enhanced green fluorescent protein reporter rats)Transplantation into the spinal cord lesion siteAcutely, at the time of the complete transection
Model: Complete low-thoracic spinal cord transection
Olfactory ensheathing cells survived longer than fibroblasts, preserved neurons and serotonergic axons, reduced inhibitory molecules in the lesion core, limited immune cell activation and infiltration and helped clear myelin debris. Fibroblasts by contrast altered astroglial scar formation and incr…
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