Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Spinal cord injury
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 5
4 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Evaluation of the Possibility of Induction of Functional Axon Regeneration in Patients With Complete Spinal Cord Injuries Using Autologous Bulbar Olfactory Ensheathing Cells and Techniques of Bridging of the Spinal Cord
Spinal Cord Injury at C5-Th10 Level With Complete Lesion · Spinal Cord Transection
Enrolment: 2 · Results not recorded
Transplantation of Autologous Olfactory Ensheathing Cells for Treatment of Complete Human Spinal Cord Injuries - a Phase I Clinical Trial
Complete Spinal Cord Injuries
Enrolment: 10 · Results not recorded
Safety, Feasibility, Efficacy of Olfactory Cell Transplantation Therapy Combined With Intensive Exercise Rehabilitation to Repair Chronic Traumatic Spinal Cord Injury
Spinal Cord Injury · Neurological Conditions · Rehabilitation Exercise
Enrolment: 30 · Results not recorded
Collection and Characterisation of Human Olfactory Ensheathing Cells (observational cell-sourcing study)
Spinal Cord Injury
Enrolment: 50 · Results not recorded
Evaluation of Safety, Feasibility and Treatment Potential for Old Stroke Patients Using Intracerebral Implantation of Olfactory Ensheathing Cells
Infarction, Middle Cerebral Artery · Ischemic Stroke · Stroke With Hemiparesis · Thromboembolic Stroke
Enrolment: 6 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatSpinal cord injuryComplete transectionSprague-Dawley (including transgenic enhanced green fluorescent protein reporter rats)Transplantation into the spinal cord lesion siteAcutely, at the time of the complete transection
Model: Complete low-thoracic spinal cord transection
Olfactory ensheathing cells survived longer than fibroblasts, preserved neurons and serotonergic axons, reduced inhibitory molecules in the lesion core, limited immune cell activation and infiltration and helped clear myelin debris. Fibroblasts by contrast altered astroglial scar formation and incr…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
