The effect of Riluzole on functional recovery of locomotion in the rat sciatic nerve crush model.
RatCrushPeripheral-nerve crushWistarMaleIntraperitonealAcute groups 6 and 8 mg/kg single dose; chronic groups 4 an…15 min after crush injury for the acute groups; chronic dosing started immediat…
Model: Sciatic nerve crush injury
Both acute and chronic riluzole administration immediately after sciatic nerve crush significantly delayed regeneration and reduced motor functional outcome, indicating that even a single early dose can delay motor recovery. The authors suggest this effect is not dependent on the anti-nociceptive a…
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