Interleukin-22 ameliorates acute severe pancreatitis-associated lung injury in mice.
MouseChemical/toxinBALB/cMaleSubcutaneousAfter intraperitoneal L-arginine administration
Model: L-arginine induced severe acute pancreatitis with associated lung injury
Recombinant IL-22 significantly reduced serum amylase and lung myeloperoxidase activity relative to the severe acute pancreatitis group and improved pancreatic and lung histological injury. It increased Bcl-2, Bcl-xL and IL-22RA1 mRNA expression and raised the phosphorylated STAT3 to STAT3 ratio co…
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