GAPDH/Siah1 cascade is involved in traumatic spinal cord injury and could be attenuated by sivelestat sodium.
RatSpinal cord injuryContusionSprague-DawleyMaleIntraperitoneal5 mg/kg and 10 mg/kgImmediately after surgery
Model: Traumatic contusion spinal cord injury produced by dropping a 10 g impactor from a height of 25 mm onto the dorsal surface of T9 and T10
Traumatic spinal cord injury induced nuclear translocation of GAPDH and Siah1 with GAPDH/Siah1 complex formation. Sivelestat sodium attenuated this cascade, suppressed apoptosis, neutrophil elastase and iNOS expression, IL-1beta and TNF-alpha production and NF-kappaB activation, and produced a sust…
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