Efficacy and Safety of Sivelestat Sodium Hydrate in Acute Lung Injury Associated With SIRS in Japan
Acute Lung Injury · Systemic Inflammatory Response Syndrome
Enrolment: 649 · Results not recorded
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Drug · Leukocyte elastase inhibitor (INHIBITOR; direct interaction)
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Acute Lung Injury · Systemic Inflammatory Response Syndrome
Enrolment: 649 · Results not recorded
Respiratory Distress Syndrome, Adult · Acute Lung Injury
Enrolment: 600 · Results not recorded
Type A Aortic Dissection · Multiple Organ Failure
Enrolment: 236 · Results not recorded
Acute Respiratory Distress Syndrome
Enrolment: 324 · Results not recorded
Cardiac Disease
Enrolment: 382 · Results not recorded
ARDS
Enrolment: 238 · Results not recorded
Septic Shock · Coagulopathy
Enrolment: 120 · Results not recorded
Coronary Heart Disease · Coronary Artery Disease
Enrolment: 62 · Results not recorded
Acute Respiratory Distress Syndrome
Enrolment: 100 · Results not recorded
Aortic Dissection · SIRS · Cardiovascular Diseases
Enrolment: 500 · Results not recorded
Acute Ischemic Stroke · Large Vessel Occlusion
Enrolment: 20 · Results not recorded
Acute Respiratory Distress Syndrome
Enrolment: 300 · Results not recorded
ARDS · Inflammatory Response
Enrolment: 560 · Results not recorded
Acute Aortic Dissection
Enrolment: 30 · Results not recorded
Aortic Dissection · ALI/ARDS
Enrolment: 168 · Results not recorded
Esophageal Cancer
Enrolment: 31 · Results not recorded
8 studies reported at therapy level; 10 evidence entries itemised.
Model: Dextran sulfate sodium in drinking water for 7 days causing acute colitis
Subcutaneous neutrophil elastase inhibitor reduced the severity of dextran sulfate sodium colitis, lowered the elevated neutrophil elastase activity in inflamed colon and decreased colonic IL-17 mRNA expression.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Traumatic contusion spinal cord injury produced by dropping a 10 g impactor from a height of 25 mm onto the dorsal surface of T9 and T10
Traumatic spinal cord injury induced nuclear translocation of GAPDH and Siah1 with GAPDH/Siah1 complex formation. Sivelestat sodium attenuated this cascade, suppressed apoptosis, neutrophil elastase and iNOS expression, IL-1beta and TNF-alpha production and NF-kappaB activation, and produced a sust…
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Model: Sodium taurocholate-induced severe acute pancreatitis with secondary lung injury
Either agent attenuated taurocholate-induced abnormalities in all parameters except serum amylase, and combined treatment gave additive protection against pancreatitis-associated lung injury.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Crush injury by 6 h direct compression of both hindlimbs with 3.5 kg blocks on each side, followed by 3 h of reperfusion
Sivelestat significantly improved survival (p = 0.032) and was accompanied by lower serum high-mobility group box 1, attenuated lung injury on histology, and suppressed high-mobility group box 1 expression in lung and liver.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Severe acute pancreatitis induced by intraductal infusion of 5% sodium taurocholate, with secondary acute lung injury
Intravenous sivelestat attenuated taurocholate-induced abnormalities in all measured circulatory, pulmonary and pancreatic parameters except serum amylase concentration.
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.
Model: Combined burn and blast injury producing acute lung injury, assessed from 0 h to 7 days post-injury
Sivelestat reduced bronchoalveolar lavage neutrophil elastase activity and ameliorated the fall in PaO2 and the rises in lavage protein, pulmonary myeloperoxidase activity, wet/dry ratio and serum TNF-alpha and IL-8 seen after burn-blast combined injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Intratracheal instillation of lipopolysaccharide 2 mg/kg to induce acute lung injury
Sivelestat or edaravone alone reduced neutrophil infiltration, histological injury and pro-inflammatory cytokines, while only edaravone lowered malondialdehyde. The combination gave additive protection relative to either single agent.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
Model: Severe burn injury with secondary acute lung injury
Sivelestat sodium hydrate raised arterial oxygen tension and reduced lung water content and histopathology score compared with untreated burns, with significant falls in neutrophil elastase and interleukin-8 in serum, lavage fluid and lung tissue. MMP-2 and MMP-9 were raised by burn injury and unch…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Extraction: mesh. Machine-extracted fields require source verification.
Extraction: not specified. Machine-extracted fields require source verification.